Thursday, February 4, 2010

Filtration in the Biopharmaceutical Industry

This timely resource offers comprehensive examinations of the mostrecent developments in the field, from prefiltration methods to final, gas, and tangential flow filtration techniques. Delineates filtration in a host of applications, including virus removal, protein binding, and sterility testing and introduces new, membrane-based technologies for the biopharmaceutical industry! Addressing quality, security, economic, process development, and regulatory topics, Filtration in the Biopharmaceutical Industry presents pre- and sterility grade filters, charge-modified filter media, and aids to filtration discusses filter quality assurance, pore size, extractables, and compatibilities in various filters examines filter design and construction analyzes integrity testing, test sensitivity, and automation furnishes novel filtration flow methods explains filter validation summarizes the U.S. Food and Drug Administration regulations governing filtration and more!

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Basic Pharmacokinetics

Basic Pharmacokinetics

This is the essential guide to the study of absorption, distribution, metabolism and elimination of drugs in the body. Pharmacokinetics and biopharmaceutics courses have been included in pharmacy curricula in the USA and Europe for several years. Pharmacokinetics is the study of absorption, distribution, metabolism and elimination of drugs in the body. Pharmacists must understand this to ensure appropriate drug regimen for patients. The scope and the intent of this textbook is to provide the reader with a basic intuitive understanding of the principles of pharmacokinetics and biopharmaceutics and how these principles, along with the equations presented in each chapter, can be applied to achieve successful drug therapy. The application of pharmacokinetics principles and equations are illustrated by providing the reader with data available in the literature. As pharmacokinetics is basically mathematical in nature, a chapter has been included to provide the reader with a basic review of the mathematical principles and graphing techniques necessary to understand pharmacokinetics. At the start of each chapter, important objectives are listed to accentuate and identify the key points of the chapter. When an important and clinically applicable equation appears in the text, a paragraph will follow explaining the significance and therapeutic applications of that equation. Additionally, this paragraph includes and explains relevant factors influencing parameters in an equation. When applicable, at the end of an important equation, a general profile illustrating the relationship between the two variables of an equation will be presented. This approach should make the subject matter much more accessible to the student. Each chapter concludes with related problem sets and problem solving exercises for the student to work through. This should enable the reader to become more adept at solving pharmacokinetic problems arising in drug therapy and understanding the applications and utility of equations in clinical pharmacokinetics and practice. As you can see from the contents, the book is organised into eighteen chapters, the first consists of mathematical principles necessary to understand pharmacokinetics and an overview of the subject matter. The remaining chapters are organised in an order which should be easy for the reader to follow. Clearance and other essential fundamental pharmacokinetic parameters are introduced early in the book as the student will need to apply these concepts in subsequent chapters. A uniform set of notation will be adopted throughout the textbook (a table of which will be at start of the book).

Lehninger Principles of Biochemistry, Fourth Edition

Lehninger Principles of Biochemistry, Fourth Edition

This is a medium-sized heavyweight classic, updated, honest and useful for physicians. The authors do not make a fuss about the wealth of data available in biochemistry, keep a cool attitude overall and somehow manage to inspire lay readers. Physicians benefit from it a lot, since the dreaded detail of molecular pathology is described at an amazing level of medical awareness and even clinical relevance. Molecular models are clear enough for the busy practitioner who has little if any real interest in the arcane wireframes of those nevertheless current substances involved in prescriptions. The print is fine, and readable, the pagesetting is minimalist but useful, and the index is workable. As for the biochemical material, in the original text of Lehninger, everything has been carefully updated, in order not to spoil the reader with the usual Big Pharma nonsense. Incredible as it may sound this is an independent book even in the Age of Virtual News. Highly Reccommended. In conclusion, here we have a book we will not buy for the beauty of our reference desk, even in the age of the instant reference.

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Pharmacology

Pharmacology

This highly acclaimed textbook is a worldwide bestseller, recognized for its emphasis on the mechanisms by which drugs act at the cellular and molecular levels and how that relates to their overall pharmacological effects and clinical uses. The 5th Edition includes four new chapters, a reorganized and expanded section on treatments for infections and cancer, and thorough updates throughout that explore new treatments and advances in molecular biology that may lead to future therapeutic options for cancer, HIV infection, osteoporosis, neurodegenerative disorders, erectile dysfunction, obesity, diabetes, atherosclerosis, cardiac failure, and more. User-friendly features include new chapter overviews reviews of relevant physiology and biochemistry boxed key points and clinical uses references and reading lists a new full-color art program and new "small print" sections that separate the more complex material from the main discussion thread in each chapter, leaving the depth of coverage to the reader's discretion.

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Protein Mass Spectrometry, Volume 52

Protein Mass Spectrometry, Volume 52

This book is designed to be a central text for young graduate students interested in mass spectrometry as it relates to study of protein structure and function as well as proteomics.
It is a definite must have work for:
- libraries at academic institutions with Master and Graduate programs in Biochemistry, Molecular Biology, Structural Biology and Proteomics;
- individual laboratories with interests covering these areas; and
- libraries and individual laboratories in the pharmaceutical and biotechnology industries.

. serves as an essential reference to those working in the field
. incorporates the contributions of prominent experts
. features comprehensive coverage and a logical structure

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MCQs in Biochemistry

MCQs in Biochemistry

Competitive Examinations are the order of the day. All Colleges conducting professional courses at PG level are admitting students based on common entrance examination, which is of objective type. In Pharmacy, M.Pharm admissions are based on qualifying the GATE enterance examination conducted by Govt. of India. In this book, The author has done good work in preparing several objective questions which help the students to face the subject in the examination with poise and confidence. The book is well balanced and consists of multiple choice questions from all the important topics like carbohydrate metabolism and other important Biochemical aspects. The typesetting and quality of printing is good. The author is also well experienced in taking up this type of work. I recommend this book to all the students preparing for GATE examination and also for Medical and Pharmacy College libraries.

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A Handbook of Bioanalysis and Drug Metabolism

A Handbook of Bioanalysis and Drug Metabolism

Recent years have seen a greater industrial emphasis in undergraduate and postgraduate courses in the pharmaceutical and chemical sciences. However, textbooks have been slow to adapt, leaving the field without a text/reference that is both instructional and practical in the industrial setting until now.

A Handbook of Bioanalysis and Drug Metabolismis a stimulating new text that examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. These three areas of research help drug developers to optimize the active component within potential drugs thereby increasing their effectiveness, and to provide safety and efficacy information required by regulators when granting a drug license. Professionals with extensive experience in drug discovery and development as well as specialized knowledge of the individual topics contributed to each chapter to create a current and well-credentialed text. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics and drugdrug interactions. The unique industrial perspective helps to reinforce theory and develop valuable analytical and interpreting skills.

This text is an invaluable guide to students in courses such as pharmaceutical science, pharmacology, chemistry, physiology and toxicology, as well as professionals in the biotechnology industry.

Methods in Enzymology, Volume 391: Liposomes, Part E

Methods in Enzymology, Volume 391: Liposomes, Part E

Liposomes are cellular structures made up of lipid molecules. Important as a cellular model in the study of basic biology, liposomes are also used in clinical applications such as drug delivery and virus studies. Liposomes Part E is a continuation of previous MIE Liposome volumes A, B, C and D.
* One of the most highly respected publications in the field of biochemistry since 1955
* Frequently consulted, and praised by researchers and reviewers alike
* Truly an essential publication for anyone in any field of the life sciences

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http://rapidshare.com/files/98356923/Meth_enzlogy_v391_liposomes_pe.zip

Filtration and Purification in the Biopharmaceutical Industry, Second Edition

Filtration and Purification in the Biopharmaceutical Industry, Second Edition

Expanded to include extensive new material on the critical role ofpurification and detailing the significant advances in filtration science and technology, this Second Edition of a classic reference provides state-of-the-science information on all aspects of filtration and purification, including current methods, processes, technologies, equipment, and the latest industry standards and regulatory requirements for the pharmaceutical and biopharmaceutical industries.

Download Link:

http://rapidshare.com/files/103744742/Fil_puri_biopharma_2Ed.zip

High Throughput Bioanalytical Sample Preparation

High Throughput Bioanalytical Sample Preparation

High Throughput Bioanalytical Sample Preparation: Methods and Automation Strategies is an authoritative reference on the current state-of-the-art in sample preparation techniques for bioanalysis. This book focuses on high throughput (rapid productivity) techniques and describes exactly how to perform and automate these methodologies, including useful strategies for method development and optimization. A thorough review of the literature is included within each of these chapters describing high throughput sample preparation techniques: protein removal by precipitation; equilibrium dialysis and ultrafiltration; liquid-liquid extraction; solid-phase extraction; and various on-line techniques.

The text begins with an introductory overview of the role of bioanalysis in pharmaceutical drug development. Fundamental understanding of the strategies for sample preparation is reinforced next, along with essential concepts in extraction chemistry. Several chapters introduce and discuss microplates, accessory products and automation devices. Particular strategies for efficient use of automation within a bioanalytical laboratory are also presented. The subject material then reviews protein precipitation, liquid-liquid extraction, solid-phase extraction and various on-line sample preparation approaches. The book concludes withinformation on recent advances in sample preparation, such as solid-phase extraction in a card format and higher density extraction plates.

Important objectives that can be accomplished when the strategies presented in this book are followed include: improved efficiency in moving discovery compounds to preclinical status with robust analytical methods; return on investment in automation for sample preparation; and improved knowledge and expertise of laboratory staff.

· Shows the reader exactly how to perform modern bioanalytical sample preparation techniques, complete with detailed strategies
· Thorough literature review and summary of published information
· Detailed discussion and examples of the method development process

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